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ADP and Pi remain bound to ATPase site. Supporting users have an ad free experience! Cross bridge cycling ends when ATP binds to the myosin head. ATP energizes the sliding process. the site of calcium regulation differs. 126.
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100% (3 ratings) 21. ATP is critical for muscle contraction as it breaks the myosin-actin cross bridge, freeing the myosin for the next contraction. ATP first binds to myosin (attachment) moving it into a high energy view the full answer. Previous question Next question.
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ATP disconnects the myosin cross bridge from the binding site on actin. 3. ATP fuels the pump that actively transports calcium ions back into the sarcoplasmic reticulum.
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The myosin head includes an ATP-binding site and an ATPase, an enzyme that breaks down ATP into ADP (adenosine diphosphate) and a phosphate group. This reaction reorients and energizes the myosin head. Notice that the ADP and a phosphate group are still attached to the myosin head. 2.
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In addition to its direct role in the cross-bridge cycle, ATP also provides the energy for the active-transport Ca ++ pumps in the SR. Muscle contraction does not occur without sufficient amounts of ATP. 1.) Energizes the power stroke of the cross bridge. 2.) Disconnects the myosin head fm the binding site on actin at the conclusion of a power stroke. 2) Hydrolysis of ATP by the Ca2+-ATPase in the sarcoplasmic provides energy for active transport of Ca2+ back into the sarcoplasmic reticulum allowing for relaxation of muscles 3) Hydrolysis of ATP by myosin energizes the the myosin cross-bridge, providing energy for force generation ATP is both an allosteric and covalent regulator *Hydrolysis of ATP by myosin energizes the cross-bridges, providing the energy for force generation (covalent action) *Binding of ATP to myosin dissociates cross-bridges bound to actin, allowing the bridges to repeat their cycle of activity (allosteric action) 18 The power stroke of the cross bridge that causes the sliding of the thin filaments 4. The binding of ATP to the cross bridge, which results in the cross bridge disconnecting from actin 5. ATP can then attach to myosin, which allows the cross-bridge cycle to start again and further muscle contraction can occur (Figure 1). The movement of the myosin head back to its original position is called the recovery stroke. Resting muscles store energy from ATP in the myosin heads while they wait for another contraction.
On application of ATP, individual cross-bridges moved nearly parallel to the filament long axis. The amplitude of the ATP-induced cross-bridge movement showed a peak at 5-7.5 nm. What is the role of calcium in the cross bridge cycle? Calcium binds to troponin, alerting its shape. Where in the cross bridge cycle does ATP hydrolysis occur?