Arnika Wagner - Assistant Professor - Karolinska Institutet

Mouse P-Selectin / CD62P PicoKine&trade ELISA Kit

SEE ALSO · Additional Selectin Antibodies including E-Selectin, L-Selectin and P-Selectin · Learn more about our ImmunoCruz® Antibody Conjugates and Cruz E. P. _. 5. µ g. /m l. C l 3 p p m.

P selectin vs e selectin

Another remarkable feature is that PMN rolling on E-selectin and subsequent ESL clustering transduce The number of CRP repeats is the major feature differentiating the type of selectin in extracellular region. In human, P-selectin has nine repeats while E-selectin contains six and L-selectin has only two. P-selectin is anchored in transmembrane region that is followed by a short cytoplasmic tail region. E-Selectin and P-Selectin are related (44% amino acid sequence identity) adhesion molecules containing multiple short complement-like repeats and an N-terminal C‑type lectin domain in their extracellular regions. E-Selectin is expressed on activated vascular endothelial cells and P-Selectin occurs on activated platelets and endothelial cells. Both E-and P-selectins are expressed on human arterial luminal endothelial cells of atherosclerotic plaques (195, 196), and mouse studies have shown that E-selectin and/or P-selectin deficiency substantially reduces the formation of atherosclerotic plaques, suggesting an overlapping function of these two selectins in the development of atherosclerotic lesions (197, 198).

P-Selectin Antibody C-20 SCBT - Santa Cruz Biotechnology

Compatible samples: cell culture supernates, serum and Hrsg . von P. Langenscheidt .

Activation of Melanocortin Receptors as a Potential Strategy to

Deep vein thrombosis (DVT) is a severe complication after total hip arthroplasty (THA). It leads to acute pulmonary embolism, a life-threatening disease. P-selectin is a 140-kDa transmembrane glycoprotein.

Blocking of selectins is therefore considered a promising therapeutic approach to treat E- and P-selectin: differences, similarities and implications for the design of P-selectin antagonists. Binder FP (1), Ernst B. Selectins form a family of Ca2+ -dependent carbohydrate binding proteins that mediate the initial step of leukocyte recruitment in the inflammatory process. Blocking of selectins is therefore considered a promising 2002-07-01 During P- and E-selectin-mediated migration of Tc1 cells, P-selectin glycoprotein ligand-1 appears to be the sole ligand for P-selectin and one of the ligands for E-selectin.
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8 When stimulated, P-selectin is translocated and up-regulated immediately, initiating the earliest phase of leukocyte recruitment into inflammatory sites. 8 Moreover, this molecule can be regulated transcriptionally by proinflammatory cytokines, such as tumor necrosis factor (TNF)–α. 12,13 E-selectin is not expressed constitutively in normal tissues but is transcriptionally up-regulated by proinflammatory to a lesser extent, E-selectin-mediated binding.
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Endomucin förhindrar vidhäftning av leukocyt-endotelceller

New!!: P-selectin and Crizanlizumab · See more » Deep vein thrombosis. Deep vein thrombosis (DVT), is the formation of a blood clot in a deep vein, most commonly P-sélectine Indeed, P - selectin variants were considered as likely candidates as possible alloantigens. En effet, certaines variantes de la P - sélectine sont considérées comme des alloantigènes potentiels.

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Activation of Melanocortin Receptors as a Potential Strategy to

E-selectin is not expressed under baseline conditions, except in skin microvessels, but is rapidly induced by inflammatory cytokines. The production of E-selectin is stimulated by the expression of P-selectin which in turn, is stimulated by tumor necrosis factor α , interleukin-1 and lipopolysaccharide . It takes about two hours, after cytokine recognition, for E-selectin to be expressed on the endothelial cell's surface. Maximal expression of E-selectin occurs around 6–12 hours after cytokine stimulation, and levels returns to baseline within 24 hours. P- and E-selectin mediate CD4+ Th1 cell migration into the inflamed skin in a murine contact hypersensitivity model.

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P-selectin was first identified in 1984, using antibodies raised against activated platelets [1, 2]. In these initial publications, P-selectin was described as a protein of molecular weight of P-selectin is constitutively expressed and stored in Weibel-Palade bodies. 8 When stimulated, P-selectin is translocated and up-regulated immediately, initiating the earliest phase of leukocyte recruitment into inflammatory sites. 8 Moreover, this molecule can be regulated transcriptionally by proinflammatory cytokines, such as tumor necrosis factor (TNF)–α. 12,13 E-selectin is not expressed constitutively in normal tissues but is transcriptionally up-regulated by proinflammatory to a lesser extent, E-selectin-mediated binding. Puri- fied P-selectin inhibited CH0:P-selectin binding to HL6O cells, but incompletely inhibited CH0:E-selectin binding to HL60 cells. However, purified soluble E- selectin inhibited CH0:P-selectin and CH0:E-selectin binding to HL60 cells equivalently and completely.

t binding curve for each receptor-ligand pair respectively expressed on the In addition to ICAM-1, the selectin family of adhesion molecules influences PMN– endothelial cell interaction. The selectins designated L-, P-, and E-selectin are a be mediated by E- and P-selectin binding to carbohydrate. Acute inflammation is PMNL versus monocyte recruitment was the observation that while optimal 15 Dec 2009 Flow experiments indicate that tumour cells roll and tether on an E- and P- selectin matrix similar to leukocytes; however, firm adhesion is mainly Members of the selectin family, E-selectin (endothelial), L-selectin (leukocyte) and P-selectin (platelet), all of which bind to fucosylated carbohydrates [1]. Selectins form a family of Ca2+ -dependent carbohydrate binding proteins that mediate the initial step of leukocyte recruitment in the inflammatory process. In addition, P-selectin expression on the surface of platelets in mice E-EL- 0057c; Elabscience) were measured by ELISA kits according to the Values are expressed as mean ± SEM. vs control; # vs FK506 group (six mice per group).